A60 PATIENT KNOWLEDGE-GAPS IN HEPATOTOXIC EFFECTS OF ACETAMINOPHEN FORMULATIONS
نویسندگان
چکیده
منابع مشابه
Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs.
A series of acetaminophen (APAP) analogs, 2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(4-hydroxyphenyl)alkanecarboxamides, bearing a heterocyclic moiety linked to the p-acylaminophenol fragment, were prepared in a general project to develop APAP analogs with modulated pharmacokinetic profiles. Unexpectedly, the products described maintained the in vivo analgesic profile, while the chara...
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BACKGROUND Recent case reports suggest that consumption of ethanol may increase the risk of liver injury induced by acetaminophen (INN, paracetamol). However, this possibility is at odds with previous clinical studies that showed that acute ethanol ingestion could protect against hepatotoxicity by inhibiting CYP-mediated acetaminophen oxidation. We tested the hypothesis that ethanol ingestion c...
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ژورنال
عنوان ژورنال: Journal of the Canadian Association of Gastroenterology
سال: 2019
ISSN: 2515-2084,2515-2092
DOI: 10.1093/jcag/gwz006.059